Table 4.
Univariable analysis of breast cancer mortality (10- and 25-year FU) in invasive lobular carcinoma
| N | 10-year FU | 25-year FU | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age (years) | 224 | 0.95 | 0.93–0.98 | 0.001 | 0.97 | 0.95–0.99 | 0.01 |
| Tumor size (mm) | |||||||
| ≤ 20 | 125 | 1.0 | 1.0 | ||||
| > 20 | 96 | 4.1 | 2.1–7.8 | < 0.001 | 3.5 | 2.1–5.7 | < 0.001 |
| Nodal status (P < 0.001)a | |||||||
| 0+ | 129 | 1.0 | 1.0 | ||||
| 1–3+ | 40 | 1.7 | 0.74–4.1 | 0.20 | 1.2 | 0.62–2.5 | 0.54 |
| > 3+ | 44 | 5.6 | 2.0–11 | < 0.001 | 3.5 | 2.0–6.0 | < 0.001 |
| Histological grade | |||||||
| 1 + 2 | 189 | 1.0 | 1.0 | ||||
| 3 | 13 | 4.1 | 1.6–10 | 0.003 | 3.8 | 1.6–8.8 | 0.002 |
| PR | |||||||
| + (≥ 1%) | 162 | 1.0 | 0.29 | 1.0 | |||
| − (< 1%) | 37 | 1.5 | 0.71–3.2 | 1.4 | 0.71–2.6 | 0.33 | |
| Ki67 | |||||||
| 0–23% | 182 | 1.0 | 1.0 | ||||
| ≥ 24% | 15 | 4.9 | 2.2–11 | <0.001 | 5.9 | 3.1–11 | <0.001 |
| AIB1 | |||||||
| Low + medium (score < 6) | 194 | 1.0 | 1.0 | ||||
| High (score 6) | 14 | 3.2 | 1.4–7.8 | 0.008 | 2.0 | 0.87–4.8 | 0.10 |
| GPER (P = 0.38)a | |||||||
| Negative (0) | 59 | 1.0 | 1.0 | ||||
| Very weak (1) | 87 | 0.79 | 0.38–1.6 | 0.54 | 0.86 | 0.47–1.6 | 0.62 |
| Weak + moderate + strong (2–4) | 63 | 0.69 | 0.300–1.6 | 0.38 | 0.87 | 0.45–1.7 | 0.69 |
| AR | |||||||
| + (> 10%) | 183 | 1.0 | 1.0 | ||||
| − (≤ 10%) | 13 | 1.8 | 0.56–5.9 | 0.33 | 1.1 | 0.34–3.5 | 0.90 |
aLog-rank test for trend