Table 1.

Clinical characteristics of the PSP patients.

Patient ID	1	2	3	4	5	6	7	8	9	10	11	12	13
Disease duration (years)	5	8	5.5	8	10	5	9	9	6	10	12	7	12
Gaze palzy at onset	Yes	Yes	Yes	Yes	No	Yes	No	Yes	Yes	No	No	Yes	Yes
Dementia*	No	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes
Cognitive dysfunction*a	+	+++	+	++	+++	++	+	+	+++	++	+++	+	+++
Apathy*a	+	−	−	+	+++	−	−	−	+++	−	+	+	−
Speech impairment*a	+	+++	++	+	++	+	++	+++	++	+	+	+++	+++
Sleep problems*a	++	++	+	++	+	++	+++	+++	+++	−	++	++	++
Nocturia*a	++	++	++	++	++	++	++	++	+++	−	+++	+++	+
Response to L-DOPA*b	+	−	+	−	+	−	++	+	−	−	++	+	+
Resting tremor*	Yes	No	No	No	No	No	Yes	No	No	Yes	No	No	No
Axial rigidity*a	+	++	++	+	+	+	+++	+	+	+	+	+	++
Bradykinesia*a	+	+	++	++	+++	+++	+	+	+++	+	++	+++	+++
Postural instability at onset	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes	No
Diagnosis	PSP-P	PSP-RS	PSP-RS	PSP-RS	PSP-F	PSP-RS	PSP-P	PSP-SL	PSP-F	PSP-RS	PSP-P/RS	PSP-P/RS	PSP-F

Data are shown for the samples donated by Bispebjerg Brain Bank, from which medical records were available. *Based on the first year after diagnosis; ^a+: Diminishable, ++: Some, +++: Intense; ^b+: Poor, ++: Good; PSP-P: PSP with parkinsonism resembling Parkinson’s disease; PSP-RS: PSP with Richardson’s syndrome; PSP-F: PSP with frontal lobe cognitive or behavioural presentations; PSP-SL: PSP with speech or language disorders¹.