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. 2019 May 23;9:7778. doi: 10.1038/s41598-019-44056-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of H2CBD upon acute, PTZ-induced primary generalised seizures in rat. Effects of vehicle, H2CBD (50, 100 200 mg kg⁻¹), and CBD (200 mg kg⁻¹) treatments upon (A) the proportion of animals exhibiting tonic-clonic seizures (gray shaded area) and (B) median (middle bars), interquartile range (upper and lower bars) and individual (•) maximum seizure severity, following PTZ administration. *P < 0.05; ***P < 0.001. Error bars in (B) show SEM. n = 12 animals per group in each case. (C) Brain and (D) blood concentrations of H2CBD (50, 100 200 mg kg⁻¹) and CBD (200 mg kg⁻¹) assessed via post-mortem samples obtained 90 minutes after cannabinoid administration. n ≥ 5 animals per group. Plots show median (middle bars), interquartile range (upper and lower bars) and individual animal (•) results. *P < 0.05; **P < 0.01.