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. 2019 May 23;9:7755. doi: 10.1038/s41598-019-44210-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo experiment humoral immune responses. Study endpoint mouse sera collected from in vivo experiment outlined in Fig. 3 along with pilot study mice from similar doses from pre-challenged status (for days −35 and −21). Mice sera were run in duplicate with each group indicating four separate animal sera tested for humoral responses. (A) Enzyme linked immunosorbent assay (ELISA) titers using plates coated with 1ug of purified ΔGrVSV-CCHFV-GPCΔ antigens and diluted various animal sera. (B) Plaque reduction neutralization test (PRNT) from diluted endpoint mouse sera with CCHFV (Strain: Turkey2004) incubated on SW-13-CDC cells. Hyperimmune mouse ascitic fluid (HMAF) was used as a positive control, kindly provided by T. Ksiazek.