Table 2.
Baseline characteristics of AP patients according to ApoB/A1 ratio quartiles.
| Characteristics | Quartile 1 (0.19–0.60) | Quartile 2 (0.61–0.80) | Quartile 3 (0.81–0.98) | Quartile 4 (0.99–1.67) | P |
|---|---|---|---|---|---|
| No. of patients | 94 | 93 | 94 | 94 | |
| SAP, n (%) | 5 (5.3) | 12 (12.9) | 20 (21.3) | 28 (29.8) | <0.001 |
| Age, year | 52.18 ± 14.31 | 51.72 ± 14.15 | 53.25 ± 15.57 | 53.59 ± 15.63 | 0.743 |
| Male sex, n (%) | 55 (58.5) | 56 (60.2) | 59 (62.8) | 60 (63.8) | 0.875a |
| Etiology, n (%) | 0.197a | ||||
| Gallstones | 62 (66.0) | 66 (71.0) | 69 (73.4) | 75 (79.8) | |
| Other | 32 (34.0) | 27 (29.0) | 25 (26.6) | 19 (20.2) | |
| BMI, kg/m2 | 23.41 ± 3.02 | 23.85 ± 3.24 | 24.57 ± 3.95 | 25.13 ± 4.36 | 0.008 |
| Smoking habit, n (%) | 24 (25.5) | 27 (29.0) | 31 (33.0) | 35 (37.2) | 0.342a |
| WBC count, ×109/L | 11.77 ± 4.52 | 12.48 ± 5.17 | 12.89 ± 5.33 | 13.42 ± 5.68 | 0.169 |
| Neutrophil count, ×109/L | 9.08 ± 3.66 | 10.37 ± 4.05 | 11.94 ± 4.55 | 13.56 ± 6.10 | <0.001 |
| Lymphocyte count, ×109/L | 1.08 ± 0.64 | 1.11 ± 0.67 | 1.04 ± 0.61 | 1.01 ± 0.62 | 0.719 |
| RBC count, ×109/L | 4.79 ± 0.73 | 4.68 ± 0.71 | 4.66 ± 0.71 | 4.55 ± 0.68 | 0.144 |
| HGB, g/L | 141.27 ± 26.48 | 145.23 ± 27.36 | 139.84 ± 24.99 | 140.77 ± 25.23 | 0.512 |
| PLT, ×109/L | 186.54 ± 60.66 | 180.55 ± 67.48 | 177.97 ± 64.24 | 173.59 ± 61.15 | 0.562 |
| CRP, mg/L | 76 (19–124) | 125 (81–234) | 171 (123–288) | 222 (145–381) | <0.001 c |
| ALT, U/L | 101 (6–754) | 99 (8–821) | 105 (15–972) | 116 (12–1061) | 0.492c |
| AST, U/L | 121 (15–831) | 129 (25–874) | 132 (20–968) | 130 (18–912) | 0.740c |
| LDH, U/L | 267.06 ± 148.42 | 316.63 ± 158.71 | 391.14 ± 172.45 | 469.89 ± 211.31 | <0.001 |
| Glucose, mmol/L | 7.72 ± 3.65 | 8.55 ± 4.79 | 8.26 ± 4.67 | 9.33 ± 4.54 | 0.093 |
| ALB, g/L | 37.76 ± 6.42 | 36.24 ± 5.85 | 34.89 ± 5.33 | 32.63 ± 5.35 | <0.001 |
| Amylase, U/L | 525 (50–2907) | 671 (81–3233) | 797 (74–3452) | 875 (88–3666) | <0.001 c |
| BUN, mmol/L | 4.35 ± 1.37 | 4.77 ± 1.52 | 5.16 ± 1.81 | 6.13 ± 2.99 | <0.001 |
| Calcium, mmol/L | 2.13 ± 0.28 | 2.10 ± 0.25 | 2.07 ± 0.24 | 2.06 ± 0.26 | 0.239 |
| TC, mmol/L | 3.84 ± 1.88 | 4.03 ± 2.10 | 3.97 ± 2.06 | 4.12 ± 2.20 | 0.822 |
| TG, mmol/L | 2.84 ± 1.72 | 3.25 ± 1.92 | 3.69 ± 2.68 | 4.21 ± 2.98 | <0.001 |
| HDL-C, mmol/L | 1.27 ± 0.32 | 1.22 ± 0.27 | 1.20 ± 0.25 | 1.16 ± 0.24 | 0.048 |
| LDL-C, mmol/L | 2.71 ± 1.33 | 2.95 ± 1.51 | 3.14 ± 1.54 | 3.39 ± 1.91 | 0.027 |
| ApoA1, g/L | 1.24 ± 0.55 | 1.18 ± 0.52 | 1.07 ± 0.45 | 0.93 ± 0.40 | <0.001 |
| ApoB, g/L | 0.68 ± 0.47 | 0.79 ± 0.49 | 0.88 ± 0.57 | 0.98 ± 0.62 | 0.002 |
| APACHE II score (at 24 h) | 3.0 (2.0–6.0) | 6.0 (3.0–10.0) | 10.0 (6.0–15.0) | 13.0 (8.0–19.0) | <0.001 c |
| Ranson score (at 48 h) | 2.0 (1.0–2.0) | 2.0 (1.0–2.0) | 4.0 (1.0–5.0) | 5.0 (3.0–7.0) | <0.001 c |
| BISAP score | 1.0 (0.0–1.0) | 1.0 (0.0–2.0) | 2.0 (1.0–2.0) | 2.5 (1.0–3.0) | <0.001 c |
| CTSI score | 2 (1–3) | 4 (1–6) | 5 (2–7) | 6 (3–8) | <0.001 c |
| Hospital stay, days | 7 (5–11) | 13 (8–27) | 26 (14–40) | 45 (20–68) | <0.001 c |
| Intensive care unit, n (%) | 11 (11.7) | 18 (19.4) | 34 (36.2) | 45 (47.9) | <0.001 a |
| 28 days mortality, n (%) | 0 (0.0) | 0 (0.0) | 2 (2.1) | 5 (5.3) | 0.019 b |
Continuous variables are described as means ± standard deviation (normal distribution) or median and interquartile range (abnormal distribution). Categorical variables are described as N (%).
aStatistical results based on χ2 analysis; bStatistical results based on Fisher’s exact test; cStatistical results based on Kruskall-Wallis test; the others were based on one way variance analysis.
SAP, severe acute pancreatitis; BMI, body mass index; WBC, white blood cell; RBC, red blood cell; HGB, hemoglobin; PLT,platelets; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; ALB, albumin; BUN, blood urea nitrogen; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low -density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoB/A1 ratio, apolipoprotein B-to-apolipoprotein A1 ratio; APACHE II, acute physiology and chronic health evaluationII; BISAP, besides index for severity in acute pancreatitis; CTSI, CT severity index.