Table 4.
The results of the joint latent class mixed model (JLCMM) for fish and fish products consumption: The number of the children reaching the endpoint of advanced islet autoimmunity (IA), and piecewise and overall hazard ratios with 95% CIs for the baseline hazard of high fish consumers in relation to the baseline hazard of low fish consumers.
| Age interval | Children with advanced IA | Unadjusted2 | P | Adjusted2,3 | P | |
|---|---|---|---|---|---|---|
| Low consumers N = 46191 (83.3%) | High consumers N = 9261 (16.7%) | |||||
| 0–24 | 96 | 3 | 0.60 (0.10, 3.73) | 0.62 (0.11, 3.67) | ||
| 2–44 | 87 | 9 | 0.66 (0.28, 1.55) | 0.65 (0.27, 1.53) | ||
| 4–64 | 46 | 5 | 0.46 (0.15, 1.41) | 0.45 (0.15, 1.38) | ||
| 6–154 | 84 | 18 | 0.83 (0.45, 1.53) | 0.81 (0.44, 1.49) | ||
| overall5 | 313 (6.8%) | 35 (3.8%) | 0.69 (0.45, 1.05) | 0.085 | 0.68 (0.44, 1.05) | 0.082 |
1Number of the children is for the unadjusted model, similar in the adjusted model.
2Values are hazard ratios with 95% CIs in parentheses.
3Model adjusted for sex of the child, genetic risk of the child and familial diabetes.
4Estimates of standard errors obtained with delta method.
5Estimates and P-values obtained from the joint latent class mixed model assuming baseline hazards of the latent classes to be proportional over the entire time period.