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PK/PD correlation in healthy volunteers. A, Linear correlation observed between percent Hb modification derived from OECs and percent Hb occupancy (derived from [voxelotor]RBC) in healthy volunteers. B, Correlation observed between Δp20 and RBC voxelotor concentrations or percent Hb occupancy. C, Correlation observed between p20 and RBC voxelotor concentrations. D, Correlation observed between p50 and RBC voxelotor concentrations
