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TEAEs occurring in >1 healthy volunteer receiving 15 days of voxelotor or placebo
| Voxelotor |
Placebo n = 6 |
||||
|---|---|---|---|---|---|
| Preferred term |
300 mg n = 6 |
600 mg n = 6 |
900 mg n = 6 |
All n = 18 |
|
| Abdominal pain | 0 | 0 | 2 (33.3) | 2 (11.1) | 0 |
| Diarrhoea | 0 | 0 | 3 (50.0) | 3 (16.7) | 0 |
| Gastroenteritis | 1 (16.7)a | 0 | 1 (16.7)a | 2 (11.1) | 0 |
| Dizziness | 2 (33.3) | 0 | 0 | 2 (11.1) | 0 |
| Headache | 1 (16.7)a | 0 | 4 (66.7)a | 5 (27.8) | 0 |
All AEs were grade 1 except for grade 2 gastroenteritis and grade 2 headache (2 of 4 events, grade 2).
