Table 2.
Adjusted Association of Door-to-Antibiotic Time and Mortality in ED Patients With Sepsis
| Variable | 1-Year Mortality |
In-Hospital Mortality |
30-Day Mortality |
90-Day Mortality |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adjusted ORa (95% CI) | P Value | Adjusted ORa (95% CI) | P Value | Adjusted ORa (95% CI) | P Value | Adjusted ORa (95% CI) | P Value | |||||
| Door-to-antibiotic time, h | 1.10 | (1.05-1.14) | < .001 | 1.16 | (1.07-1.26) | < .001 | 1.12 | (1.06-1.18) | < .001 | 1.09 | (1.04-1.15) | < .001 |
| Door-to-antibiotic time > 1 h | 1.26 | (0.98-1.62) | .070 | 1.32 | (0.91-1.92) | .14 | 1.12 | (0.83-1.52) | .46 | 1.24 | (0.94-1.65) | .13 |
| Door-to-antibiotic time > 3 h | 1.27 | (1.13-1.43) | < .001 | 1.42 | (1.13-1.80) | .003 | 1.28 | (1.08-1.52) | .005 | 1.32 | (1.14-1.52) | < .001 |
| Door-to-antibiotic time interval | ||||||||||||
| ≤ 1 h | Reference | Reference | Reference | Reference | ||||||||
| > 1 to ≤ 2 h | 1.19 | (0.91-1.56) | .20 | 1.29 | (0.87-1.93) | .21 | 0.97 | (0.70-1.35) | .85 | 1.17 | (0.86-1.58) | .31 |
| > 2 to ≤ 3 h | 1.20 | (0.92-1.56) | .18 | 1.20 | (0.79-1.82) | .39 | 1.19 | (0.86-1.65) | .30 | 1.17 | (0.87-1.59) | .30 |
| > 3 to ≤ 4 h | 1.40 | (1.06-1.85) | .018 | 1.61 | (1.03-2.53) | .036 | 1.29 | (0.90-1.83) | .16 | 1.47 | (1.07-2.01) | .019 |
| > 4 to ≤ 5 h | 1.41 | (1.04-1.91) | .025 | 1.39 | (0.82-2.37) | .22 | 1.28 | (0.86-1.91) | .23 | 1.43 | (1.00-2.03) | .049 |
| > 5 to ≤ 6 h | 1.84 | (1.31-2.57) | < .001 | 2.28 | (1.26-4.16) | .007 | 1.87 | (1.20-2.92) | .006 | 1.90 | (1.28-2.81) | .001 |
| > 6 h | 2.02 | (1.40-2.90) | < .001 | 3.45 | (1.78-6.67) | < .001 | 2.06 | (1.25-3.40) | .004 | 1.74 | (1.11-2.73) | .015 |
a
Adjusted for pooled triage acuity score; receipt of prehospital medical care; MEDS score; SOFA score; initial vital signs (systolic blood pressure, abnormal Glasgow Coma Scale, heart rate, temperature, respiratory rate, and oxygen saturation); ED disposition (ICU vs ward); comorbidity score; marital status; insurance type; age; sex; Hispanic ethnicity or non-white race; hospital; non-English preferred language; initial WBC count; and initial lactate level tested and > 2 mmol/L. See Table 1 legend for expansion of abbreviations.