Figure 2.

The cAMP signalling pathway was significantly activated in MTX‐resistant CRC cells (A) A rank plot of the GSEA results showing the top 9 significantly activated and inactivated signalling pathways, including the cAMP signalling pathway. P (adjusted) <0.05. (B) A dotplot of the GSEA results indicating that the cAMP signalling pathway was activated in MTX‐resistant CRC cells. P (adjusted) <0.05. (C) A ridgeplot based on the GSEA results indicating that the cAMP signalling pathway was activated. P (adjusted) <0.05. (D) A GSEAplot indicating that the NES value of the cAMP signalling pathway was greater than zero and that this pathway was significantly enriched in MTX‐resistant CRC cells