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. 2019 Apr 17;23(6):3808–3823. doi: 10.1111/jcmm.14071

Figure 4.

Figure 4

KCNQ1OT1 influenced cell cycle progression and apoptosis in MTX‐resistant CRC cells (A, B) The cell cycle stage was detected by flow cytometry in HT29 and HT29/MTX cells to explore the effect of KCNQ1OT1. *P < 0.05 compared with the HT29 cells, #P < 0.05 compared with the HT29/MTX cells. (C, D) The cell cycle stage was detected by flow cytometry in Caco2 and Caco2/MTX cells to explore the effect of KCNQ1OT1. *P < 0.05 compared with the Caco2 cells, #P < 0.05 compared with the Caco2/MTX cells. (E, F) Cell apoptosis was detected by flow cytometry in HT29 and HT29/MTX cells to explore the effect of KCNQ1OT1. *P < 0.05 compared with the HT29 cells, #P < 0.05 and ##P < 0.01 compared with the HT29/MTX cells. (G, H) Cell apoptosis was detected by flow cytometry in Caco2 and Caco2/MTX cells to explore the effect of KCNQ1OT1. *P < 0.05 compared with the Caco2 cells, #P < 0.05 compared with the Caco2/MTX cells