Figure 3.

Alpha lipoic acid promoted translocation of Nrf2 from cytoplasm to nucleus and enhanced Nrf2 binding. A, The representative photomicrographs showing Nrf2 immunohistochemistry of tissue from different group after TBI. (B, C) The total and nuclear Nrf2 expression after ALA treatment in rat with TBI was measured by Western blot. Bars represent the mean ± SD. *P < 0.05, ***P < 0.001 compared with the sham group; ^# P < 0.05, ^## P < 0.01 versus TBI + vehicle group. Black arrows: Nrf2 positive neuron cell