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. 2019 Apr 1;23(6):3784–3794. doi: 10.1111/jcmm.14292

Table 1.

Reported examples of skeletal muscle differentiation from iPSCs

Study Differentiation method Modelled disease Some achievements
84 MyoD transfection Facioscapulohumeral muscular dystrophy Generation of isogenic control clones. Gene correction (CRISPR/Cas9)
85 MyoD transfection Duchenne muscular dystrophy Evaluation of exon skipping in disease‐specific myocytes
72 Small molecules Pompe disease Gene correction (CRISPR/Cas9) Large‐scale expansion
71 Pax7 transfection Myotonic dystrophy 1 NA
86 Small molecules Duchenne muscular dystrophy Generation of transplantable myogenic cells
87 MyoD transfection Muscular dystrophy High‐throughput drug screening
88 MyoD transfection Infantile‐onset Pompe disease NA
89 MyoD transfection Limb girdle muscular dystrophy type 2C iPSCs derived from urine cells Gene correction (CRISPR/Cas9)
90 MyoD transfection Amyotrophic lateral sclerosis Study of neuromuscular microenvironment and generation of functional myotubes

NA, not applicable.