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. 2019 May 17;10:499. doi: 10.3389/fphar.2019.00499

FIGURE 4.

FIGURE 4

Sorcs2−/− mice do not display alcohol withdrawal symptoms. For 14 days, the only drinking source for WT and Sorcs2−/− mice was water containing alcohol, which increased in concentration over time. Control mice, continued to have normal tap water. On day 15, ethanol was withdrawn from the water. Hereafter, the mice were tested for handling-induced convulsion every 2 h after alcohol withdrawal. Sorcs2−/− mice seemed non-affected by the alcohol and its withdrawal. Accordingly, WT had significantly more severe convulsions (∗∗∗∗P < 0.0001 at 4, 6, 8, 10, 12 and ∗∗ P < 0.01 at 24 h after alcohol withdrawal, compared to Sorcs2−/− mice). Interestingly, higher level of convulsion was also observed in the WT control group compared to Sorcs2−/− control group (###P = 0.0001 and #P < 0.01) (n = 2–3 for each ethanol-naïve group and n = 5–8 for each ethanol-treated group). The results are expressed as mean ± SEM. The error bars in some data points are smaller than the symbols and therefore not visible.