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. Author manuscript; available in PMC: 2019 May 24.
Published in final edited form as: Neurotoxicology. 2018 Oct 16;70:26–32. doi: 10.1016/j.neuro.2018.10.006

Fig. 4.

Fig. 4.

Effects of prior CORT exposure on brain and peripheral inflammation. Mice exposed to the organophosphate, AChE inhibitor DFP exhibit increases in proinflammatory cytokines in the brain and the liver. Unlike the brain, the inflammation observed in the periphery is coincident with liver damage and this inflammatory signaling increases the levels of circulating cytokines. Prior exposure to CORT primes the neuroinflammatory response to DFP, but inhibits the damage-induced inflammation in the liver and the secondary response in the blood.