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. 2019 May 17;10:303. doi: 10.3389/fendo.2019.00303

Figure 4.

Figure 4

4-PBA alleviated hepatic ERS in SCH mice. We established SCH mouse model using MMI. When MMI was applied for 14 weeks, 4-PBA was given at a dose of 100 mg/kg·BW·d for 4 weeks, and mice were divided into four subgroups (as shown in Supplementary Figure 1): vehicle treated control mice group (con + veh group), 4-PBA treated control mice group (con + 4-PBA group), vehicle treated SCH mice group (SCH + vehicle group), and 4-PBA treated SCH mice group (SCH + 4-PBA group). (A) The protein expression of ERq29 was detected by western blot (n = 4–6). (B) The mRNA expression of ERq29 was detected by Real-time PCR. (C) The expression of proteins in the Bip/IRE1α/XBP-1 pathway were detected by western blot (n = 4–6). The data are presented as the mean ± SD. *p < 0.05 compared with control. #p < 0.05 compared with SCH.