Table 1.

Motor function of different AD mouse models.

Mouse model	References	Test age	Sex	Open Field	Rotarod	Balance beam walk	String susp. task	Grip strength tasks
J20 APPSweK670N/M671L + IndV 717F (Mucke et al., 2000)	Harris et al., 2010	1) 2–3 m	♂	↑	–	–	–	–
		2) 5–7 m	♂	↑	–	–	–	–
	Chang et al., 2015	1) 5 m	–	ns	ns	–	–	–
Tg2576APP695SweK670N/M671L (Hsiao et al., 1996)	King and Arendash, 2002	1) 3 m	♀♂	↑	–	↓	ns	–
		2) 9 m	♀♂	ns	–	ns	ns	–
		3) 14 m	♀♂	ns	–	↓	↓	–
		4) 19 m	♀♂	ns	–	↓	↓	–
	Dineley et al., 2002	1) 5 m	♀♂	ns	ns	–	–	–
		2) 9 m	♀♂	ns	ns	–	–	–
	Perucho et al., 2010	1) 12 m	♂	ns	ns	–	–	–
APP23APP751SweK670N/M671L (Sturchler-Pierrat et al., 1997)	van Dam et al., 2003	1) 6–8w	♂	ns	ns	–	–	–
		2) 3 m	♂	ns	↓	–	–	–
		3) 6 m	♂	↓	↓	–	–	–
	Lalonde et al., 2005a	1) 24 m	♀	ns	↑	ns	↑	–
APP/PS1APPSweK670N/M671L/PS1ΔE9 (Jankowsky et al., 2001)	Kuwabara et al., 2014	1) 3 m	♀♂	–	↓	ns	–	–
		2) 5–6 m	♂	–	↓	ns	–	–
	Singh et al., 2017	1) 4 m	♀♂	–	ns	–	–	–
		2) 8 m	♀♂	–	ns	–	–	–
		3) 12 m	♀♂	–	ns	–	–	–
	Lalonde et al., 2004	1) 7 m	♀♂	ns	ns	ns	ns	ns
APP+PS1APPSweK670N/M671L + PS1M146L (Holcomb et al., 1999)	Holcomb et al., 1999	1) 3 m	♀♂	–	–	–	ns	–
		2) 6 m	♀♂	–	–	–	ns	–
		3) 9 m	♀♂	–	–	–	ns	–
	Arendash et al., 2001	1) 5–7 m	♀♂	ns	–	↓	ns	–
		2) 15–17 m	♀♂	↑	–	↓	↓	–
	Sadowski et al., 2004	1) 8 m	–	ns	–	ns	–	–
		2) 22 m	–	ns	–	ns	–	–
	Ewers et al., 2006	1) 12 m	♀♂	–	↓	–	–	–
APP/PS1KIAPPNLh/NLh × PS1P264L/P264L (Flood et al., 2002)	Webster et al., 2013	1) 7 m	♀♂	ns	ns	ns	–	ns
		2) 11 m	♀♂	ns	ns	ns	–	ns
		3) 15 m	♀♂	ns	ns	ns	–	ns
		4) 24 m	♀♂	ns	ns	ns	–	ns
5XFADAPPsweK670N/M671, FloI716V,LonV 717I + PS1M146/L286V (Oakley et al., 2006)	Jawhar et al., 2012	1) 3 m	♀	–	–	ns	ns	–
		2) 6 m	♀	–	–	ns	ns	–
		3) 9 m	♀	ns	–	↓	↓	–
		4) 12 m	♀	ns	–	↓	↓	–
	O’Leary et al., 2018a	1) 3–4 m	♀♂	ns	ns	ns	ns	ns
		2) 6–7 m	♀♂	♀♂	ns	ns	♂↓	↓
		3) 9–10 m	♀♂	ns	↓	↓	ns	ns
		4) 12–13 m	♀♂	↓	↓	↓	♂↓	↓
		5) 15–16 m	♀♂	↓	↓	↓	↓	↓
	Shukla et al., 2013	1) 6 m	♀♂	ns	ns	–	–	–
		2) 9 m	♀♂	–	ns	–	–	–
		3) 12 m	♀♂	–	↓	–	–	–
	current study	1) 3 m	♀	ns	ns	ns	ns	ns
		2) 7 m	♀	↓	ns	ns	ns	ns
3xTg APPSweK670M/N671L, PS1M136V, MAPTP301L (Oddo et al., 2003)	Oore et al., 2013	1) 2 m	♀♂	–	↑	–	–	–
		2) 6 m	♀♂	–	↑	–	–	–
		3) 9 m	♀♂	–	↑	–	–	–
		4) 12 m	♀♂	–	↑	–	–	–
		5) 15 m	♀♂	–	↑	–	–	–
	Stover et al., 2015	1) 6 m	♀♂	–	↑	ns	ns	↓
	Garvock-de Montbrun et al., 2019	1) 16 m	♀♂	–	↑	ns	ns	ns
	Filali et al., 2012	1) 12–14 m	♀	↓	↓	–	–	–
	Gulinello et al., 2009	1) 15–18 m	♀♂	↓	–	ns	–	–
TBA 42 AβpE3-42 (Wittnam et al., 2012)	Meissner et al., 2014	1) 3 m	♀♂	–	–	ns	↓	ns
		2) 6 m	♀♂	–	–	↓	↓	↓
		3) 12 m	♀♂	–	–	↓	↓	↓
	Wittnam et al., 2012	1) 3 m	♀	–	–	ns	–	–
		2) 6 m	♀	–	–	ns	–	–
		3) 12 m	♀	–	–	↓	–	–
	Lopez-Noguerola et al., 2018	1) 3–4 m	♀♂	–	–	ns	ns	ns
		2) 5–6 m	♀♂	–	–	↓	↓	↓
Tg4-42 Aβ4-42 (Bouter et al., 2013)	Lopez-Noguerola et al., 2018	1) 3–4 m	♀♂	–	–	ns	ns	ns
		2) 5–6 m	♀♂	–	–	ns	ns	ns
	Current study	1) 3 m	♀	ns	↓	ns	ns	ns
		2) 7 m	♀	ns	↓	↓	ns	ns

w, weeks; m, months; ns, not significant.