Table 4. Published trials of renal denervation for arterial hypertension in alphabetical order (updated March 2019).
| Trials | N | RDN system | Trials | N | RDN system |
| Randomized sham-controlled trials | Non-randomized trials | ||||
| RADIANCE-HTN SOLO | 146 | ParadiseTM (ReCor Medical) | ACHIEVE | 96 | ParadiseTM (ReCor Medical) |
| RADIANCE REINFORCE | 51 | VessixTM (Boston Scientific) | EncoreD | 109 | Symplicity FlexTM (Medtronic) and others |
| ReSET | 69 | Symplicity FlexTM (Medtronic) | EnligHTN 1 | 46 | EnligHTNTM (St. Jude Medical) |
| SYMPLICITY-FLEX | 71 | Symplicity FlexTM (Medtronic) | EnligHTN 2 | 133 | EnligHTNTM (St. Jude Medical) |
| SPYRAL HTN-OFF MED | 80 | Symplicity SpyralTM (Medtronic) | EnligHTN 3 | 39 | EnligHTNTM (St. Jude Medical) |
| SPYRAL HTN-ON MED | 80 | Symplicity SpyralTM (Medtronic) | GLOBAL SYMPLICITY REGISTRY | 2583 | Symplicity FlexTM (Medtronic) |
| Symplicity SpyralTM (Medtronic) | |||||
| Symplicity HTN-3 | 535 | Symplicity FlexTM (Medtronic) | Heidelberg Registry | 63 | Symplicity FlexTM (Medtronic) |
| WAVE IV | 81 | Surround SoundTM (Kona Medical) | Irish Registry | 31 | Symplicity FlexTM (Medtronic) |
| Subtotal | 1113 | Kazakhstan Registry | 63 | Symplicity FlexTM (Medtronic) | |
| Randomized controlled trials (no sham control) | Portugal Registry | 31 | Symplicity FlexTM (Medtronic), EnligHTNTM (St Jude), OneShotTM (Covidien) | ||
| DENERHTN* | 106 | Symplicity FlexTM (Medtronic) | RAPID | 50 | OneShotTM (Covidien) |
| DENERVHTA# | 27 | Symplicity FlexTM (Medtronic) | Reduce HTN | 146 | VessixTM (Boston Scientific) |
| INSPIReD | 15 | EnligHTNTM (St Jude) | SPYRAL FIM | 50 | Symplicity SpyralTM (Medtronic) |
| PRAGUE 15# | 106 | Symplicity FlexTM (Medtronic) | Swedish Registry | 252 | Symplicity FlexTM (Medtronic), Symplicity SpyralTM (Medtronic), EnligHTNTM (St Jude), OneShotTM (Covidien), VessixTM (Boston Scientific), ParadiseTM (ReCor Medical) |
| RADIOSOUND# | 120 | ParadiseTM (ReCor Medical) versus Symplicity SpyralTM (Medtronic) | SYMPLICITY HTN-1 | 50 | Symplicity FlexTM (Medtronic) |
| RDN OSA | 60 | Symplicity FlexTM (Medtronic) | TREND Registry | 191 | Symplicity FlexTM (Medtronic), Symplicity SpyralTM (Medtronic), EnligHTNTM(St Jude), |
| RDN OSLO# | 19 | Symplicity FlexTM (Medtronic) | UK Registry | 253 | SymplicityFlexTM (Medtronic), SymplicitySpyralTM (Medtronic), VessixTM (Boston Scientific), EnligHTNTM (St Jude), OneShotTM (Covidien) |
| SYMPATHY | 139 | Symplicity FlexTM (Medtronic) | Subtotal | 4186 | |
| SYMPLICITY HTN-Japan | 41 | Symplicity FlexTM (Medtronic) | |||
| Symplicity HTN-2 | 106 | Symplicity FlexTM (Medtronic) | |||
| Subtotal | 739 | ||||
| Total | 6038 |
* Standardized stepped-care antihypertensive control; # Active comparator control. RDN, renal denervation.