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. 2019 May 9;10:517. doi: 10.3389/fphys.2019.00517

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Copyright © 2019 Escobar-Henriques and Joaquim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pro- and anti-mitophagic roles of mitofusins. Mitofusins are reported to induce and inhibit mitophagy through a variety of processes. Pro-mitophagic roles of mitofusins can be promoted by (1) phosphorylation of MFN2 by PINK1, and subsequent recruitment of Parkin to mitochondria, (2) Gp78-mediated ubiquitylation of MFN1, and (3) SIRT1-mediated deacetylation of MFN2. Anti-mitophagic roles have been described for Mitofusin 2 via (1) MULAN-mediated ubiquitylation, (2) increase of ER-mitochondria contacts directly mediated by MFN2, and (3) mutations in MFN2 associated with Charcot-Marie-Tooth Type 2A (CMT2A) neuropathy.

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