Skip to main content
. 2019 May 9;10:517. doi: 10.3389/fphys.2019.00517

Figure 3.

Figure 3

Structure and topology models of mitofusins. (A) Linear structure of mitofusin, with the GTPase domain locating at the N-terminal, one hydrophobic heptad repeat (HR1), the transmembrane anchor(s), and a second hydrophobic heptad repeat (HR2). (B) Crystal structure of MFN1 and MFN2 modeled on BDLP and mini-MFN1, according to the first topology proposed, with two transmembrane domains and both the N- and C-terminus facing the cytosol (Rojo et al., 2002; Low and Löwe, 2006; Low et al., 2009; Qi et al., 2016; Cao et al., 2017). (C) Structural scheme of MFN1 and MFN2 according to the second topology proposed with a single spanning-membrane domain, instead of two, and the C-terminus residing in the IMS and not facing the cytosol (Mattie et al., 2018).