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Residues, E3 ligases, and processes regulating MFN1 (A) MFN2 (B). Representation of the triggers identified to modify mammalian mitofusins by ubiquitylation, phosphorylation, and acetylation. The enzymes evolved in each case, and the cellular outcome is also depicted. The vertical bar on each side of the structure denotes that the residues modified by ubiquitylation in MFN1 or MFN2 are not known. See text for details.
