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. 2019 May 23;19:147. doi: 10.1186/s12935-019-0852-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 12 — Schematic representation of the underlying mechanism of miR-137 in CC. In CC, the expression of miR-137 decreased significantly and the expression of GREM1 increased significantly. MiR-137 can target and inhibit the expression of GREM1 gene. Inhibition of miR-137 could promote the expression of GREM1, and GREM1 could promote the expression of TGF-β1, Smad2, Smad3, N-cadherin and Vimentin. Overexpression of miR-137 could inhibit the CC cell proliferation, migration and EMT while inducing apoptosis. CC cervical cancer, GREM1 gremlin-1, miR-137 microRNA-137