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. 2019 May 23;17:50. doi: 10.1186/s12964-019-0367-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The total signaling pathway. ERα-induced estrogen effects promoted the expression of NOTCH1 by binding NOTCH1 promoter at − 1364 and − 1188 bp, EZH2 was recruited by ERα and acts as a cofactor to assist ERα-induced estrogen effects in regulating NOTCH1 in PCa. The ERα-induced estrogen effects may promote CD49f^Hi EMT-PCBSLCs metastasis to other organs

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