Table 2.

Agreement of p16/Ki-67 results

	Initial training			Additional training
	OPA	p value	Kappa (95% CI)	OPA	p value	Kappa (95% CI)
LAB1-LAB2	86.8	0.015	0.73 (0.61–0.85)	93.8	0.289	0.87 (0.79–0.96)
LAB1-LAB3	86.0	0.480	0.72 (0.60–0.84)	93.0	0.505	0.86 (0.77–0.95)
LAB2-LAB3	82.2	0.004	0.64 (0.51–0.77)	93.0	0.046	0.86 (0.77–0.95)
LAB1-LAB2-LAB3	77.5	0.002	0.70 (0.59–0.78)	89.9	0.058	0.86 (0.78–0.92)

OPA … Overall percent agreement, LAB1 … Laboratory1, LAB2 … Laboratory2, LAB3 … Laboratory3