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. 2019 May 23;38:216. doi: 10.1186/s13046-019-1197-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effects of Thiostrepton, Danusertib and Volasertib on mononuclear cells from three patients resistant to TKIs without mutations on BCR-ABL1 . Reduction of clonogenic growth of cells from 3 patients with CML (blue, red and black curves) as compared to a healthy donor (HD; green curve) in the presence of increasing doses of Thiostrepton (0.05–0.30 μM), Danusertib and Volasertib (0.025–0.100 μM). Nonlinear regression analyses (GraphPad Software Inc., La Jolla, CA) were used to calculate the lethal dose (LD50) of different drugs in cell lines and in primary patient cells