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. 2019 May 23;20:101. doi: 10.1186/s12931-019-1049-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The three clusters of COPD patients stratified represented as glyphs. Clusters (G1 to G3) were the result of quantitative unsupervised clustering based on a dissimilarity matrix that captures the distribution of classified parenchymal patterns recognized by CALIPER. G1 was characterized by predominant Normal (dark green) and Mild LAA (light green) patterns, whereas G2 by predominant Moderate LAA (light blue) pattern and G3 by predominant Severe (dark blue) and Moderate LAA (light blue) patterns