Table 4.
Relationship among ESI values and functional data across the groups of patients with various degrees of emphysema
| Emphysema severity | N | ESI score | FEV1% | FVC % | FEV1/FVC % | TLC % | RV % | FRC % | DLco % |
|---|---|---|---|---|---|---|---|---|---|
| VIDA | |||||||||
| NE | 57 | 1.1 (1.5) | 76.1 (23.6) | 93.5 (22.8) | 63.1 (8.0) | 100.1 (11.8) | 115.0 (30.5) | 109.3 (18.2) | 79.7 (22.9) |
| ME | 58 | 3.1 (2.6) | 63.6 (23.9) | 91.4 (21.0) | 54.1 (10.2) | 106.9 (18.8) | 134.1 (51.7) | 125.3 (31.0) | 75.6 (21.6) |
| SE | 79 | 6.8 (2.5) | 49.9 (23.7) | 91.2 (27.8) | 42.4 (10.8) | 115.2 (15.1) | 157.6 (48.2) | 147.9 (33.7) | 55.9 (19.8) |
| ANOVA / Welch’s test p | <.001 | <.001 | .002 | <.001 | <.001 | <.001 | <.001 | <.001 | |
| Imbio LDA | |||||||||
| NE | 86 | 1.5 (1.8) | 72.6 (22.9) | 92.9 (20.9) | 60.5 (9.2) | 101.1 (15.6) | 118.2 (42.0) | 111.5 (23.7) | 78.9 (23.2) |
| ME | 46 | 4.6 (2.7) | 63.8 (27.5) | 94.1 (25.2) | 52.1 (10.1) | 111.9 (15.0) | 145.6 (47.4) | 135.4 (30.5) | 72.6 (18.1) |
| SE | 62 | 7.7 (3.3) | 44 (18.8) | 88.6 (28.2) | 39.6 (9.5) | 115.7 (15.5) | 160.7 (46.2) | 152.1 (32.5) | 51.9 (18.9) |
| ANOVA / Welch’s test p | <.001 | <.001 | .442 | <.001 | <.001 | <.001 | <.001 | <.001 | |
| CALIPER | |||||||||
| G1 | 95 | 1.7 (2.1) | 71.9 (23.7) | 92.8 (21.9) | 59.8 (9.6) | 101.2 (14.6) | 118.7 (39.4) | 113.2 (24.3) | 78.4 (23.2) |
| G2 | 65 | 5.4 (2.8) | 59.7 (24.9) | 97.1 (26.5) | 48.8 (11.0) | 113.4 (16.5) | 145.9 (47.6) | 137.9 (30.7) | 65.6 (19.0) |
| G3 | 34 | 8.0 (1.7) | 36.8 (14.3) | 79.5 (23.2) | 36.5 (8.0) | 118.2 (13.6) | 177.3 (44.0) | 163.4 (29.9) | 48.1 (18.5) |
| ANOVA / Welch’s test p | <.001 | <.001 | .002 | <.001 | <.001 | <.001 | <.001 | <.001 | |
Differences among groups were assessed by analysis of variance and Welch’s tests, expressed in italics and in bold if significant. Values are expressed as mean (SD). DLco % percent predicted diffusing lung capacity for carbon monoxide, FEV1% percent predicted forced expiratory volume in 1 s, FRC% percent predicted functional residual capacity, FVC% percent predicted forced vital capacity, %LAA-950insp percentage of lung attenuation area with values <−950 Hounsfield Units at inspiratory CT scan, ME (moderate emphysema, 6 ≤ %LAA-950insp < 14 if VIDA or 6 ≤ %pLDA < 14 if Imbio LDA), NE (no emphysema, %LAA-950insp < 6 if VIDA or %pLDA < 6 if Imbio LDA), RV% percent predicted residual volume, SE (severe emphysema, %LAA-950insp ≥ 14 if VIDA or %LAA-950insp ≥ 14 if Imbio LDA), TLC% percent predicted total lung capacity