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. 2019 May 23;38:217. doi: 10.1186/s13046-019-1232-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Triptolide inhibits tumorigenesis in Apc^Min/+ mice and disrupts organoid growth. a The workflow of the triptolide treatment in the Apc^Min/+ mouse model. b The small intestines from 6-month-old Apc^Min/+ mice treated with or without triptolide for 3 months. Scale bar: 1 cm. c H&E staining of the small intestines from 6-month-old Apc^Min/+ mice treated with or without triptolide for 3 months. Scale bar: 1 mm. Tumor number and size distribution from Apc^Min/+ mice treated with or without triptolide were analyzed. ** P < 0.01. d Organoids isolated from Apc^Min/+ mice were treated with or without 5 nM of triptolide and pictures were taken under a microscope. Scale bar: 25 μm. Organoids were treated with different concentration of triptolide for 72 h and cell viability (ATP level) was measured. ** P < 0.01