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. 2019 May 23;12:70. doi: 10.1186/s12920-019-0535-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Experimental validation of predicted miRNAs. a Cell proliferation assays in human lip fibroblasts treated with the indicated mimics of miRNAs. Negative control (control, light blue), miR-369-3p (orange), miR-655-3p (gray), miR-374a-3p (yellow), miR-374b-3p (blue), miR-497-5p (light green), and miR-124-3p (dark blue). *** p < 0.001. b Quantitative RT-PCR for the indicated genes after treatment with negative control (light blue) or miR-655-3p mimic (orange). * p < 0.05, ** p < 0.01, *** p < 0.001. c Quantitative RT-PCR for the indicated genes after treatment with negative control (light blue) or miR-497-5p mimic (orange). * p < 0.05, ** p < 0.01, *** p < 0.001