Table 3.
MicroRNA (miRNA) enrichment analysis of 161 human CL/P genes (FDR < 0.1)
| miRNA family ID | miRNA name | Gene symbol | FDR (BH) |
|---|---|---|---|
| miR-154 | hsa-miR-369-3p | CHD7, DMD, EYA1, GABRB3, GREM1, HOXB3, NOG, PAX6, TIMP2, TULP4, BAG4, FZD6, YOD1 | 0.03 |
| miR-154 | hsa-miR-655-3p | BCL2, DMD, EN2, GREM1, HOXB3, MAFB, MID1, NTN1, PAX6, SATB2, TULP4, CYP1A1, FZD6, YOD1 | 0.03 |
| miR-374 | hsa-miR-374a-5p | CHD7, DMD, EYA1, FGFR2, FOXG1, HECTD1, HOXB3, JARID2, MSX1, NOG, NTN1, PAX6, RAD51, RHPN2, RUNX2, TGFA, TNS1, WNT5A, WNT5B, YOD1, EN2, FZD6 | 0.07 |
| miR-374 | hsa-miR-374b-5p | CHD7, DMD, EYA1, FGFR2, FOXG1, HECTD1, HOXB3, JARID2, MSX1, NOG, NTN1, PAX6, RAD51, RHPN2, RUNX2, TGFA, TNS1, WNT5A, WNT5B, YOD1, EN2, FZD6 | 0.07 |
| miR-497 | hsa-miR-497-5p | AXIN2, BAG4, BCL2, CHD7, CRISPLD2, EN2, EYA1, FGF1, FGF2, FGFR1, FGFR2, FOXP2, FZD6, HECTD1, JARID2, PAX7, RHPN2, SATB2, SLC6A4, WNT3A, YOD1, MTHFR, RUNX2, TFAP2A, TPM1 | 0.07 |
| miR-124 | hsa-miR-124-3p | GABRB3, GCH1, JAG2, KIF2A, MTR, MYH9, ROR2, RYK, TANC2, ARHGAP29, COL4A4, DVL2, EFNB1, FGF1, FGFR1, FOXF2, GREM1, HOXB3, KIF7, PDGFC, PEMT, PKP1, RAD51, RUNX2, SOX9, TBX22, TP63, TPM1, WNT5B | 0.09 |
| miR-1271 | hsa-miR-1271-3p | CBS, DCAF7, FZD6, RAD51, YOD1 | 0.09 |
| miR-203 | hsa-miR-203a-3p | E2F1, EN2, GREM1, HECTD1, KIF2A, PAX6, RUNX2, SMAD2, TP63 | 0.09 |
| miR-27 | hsa-miR-27b-3p | BCL3, CHD7, COL21A1, DVL2, EN2, EYA1, FGF1, FOXP2, GABRB3, GCH1, GREM1, HOXB3, PAX9, RARA, SATB2, SMAD1, STK32B, SMAD2, DCAF7, PAX3, PAX7, SEC16A, WNT9B | 0.09 |
| miR-154 | hsa-miR-300 | CR1, DVL2, FGF1, FGFR2, FOXF2, FOXP2, GABRB3, GAD1, HECTD1, JAG2, MID1, PDGFC, TANC2, TGFB3, WNT5A, CRISPLD2, GREM1, PHF8 | 0.09 |
| NA | hsa-miR-3678-3p | E2F1, GABRB3, JARID2, SLC6A4, YOD1 | 0.09 |
| miR-368 | hsa-miR-376b-3p | CRISPLD2, EN2, FGFR1, MYH9, PAX3, PAX6, PRSS35, TANC2, FGF2, FOXG1 | 0.09 |
| miR-154 | hsa-miR-381-3p | CR1, DVL2, FGF1, FGFR2, FOXF2, FOXP2, GABRB3, GAD1, HECTD1, JAG2, MID1, PDGFC, TANC2, TGFB3, WNT5A, CRISPLD2, GREM1, PHF8 | 0.09 |
| miR-503 | hsa-miR-503-5p | HECTD1, JARID2, MAFB, WNT3A, BCL2, DHFR, FGF2, FGFR1, SMAD2, TFAP2A | 0.09 |
| miR-550 | hsa-miR-550a-3-5p | CBS, DCAF7, FZD6, RAD51, YOD1 | 0.09 |
| miR-550 | hsa-miR-550a-5p | CBS, DCAF7, FZD6, RAD51, YOD1 | 0.09 |
BH Benjamini–Hochberg adjustment for multiple test correction [23]