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. 2019 May 23;19:490. doi: 10.1186/s12885-019-5708-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Bright field image and SHG images of two representative cores of RCC grade 1 and grade 4. The fibers in the zoomed-in region of grade 1 have a mesh-like organization, while those in the grade 4 are more aligned. Image brightness and contrast were adjusted for enhanced visualization using MATLAB. Scale bar = 50 um