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. 2019 May 23;38:219. doi: 10.1186/s13046-019-1235-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — AZD9291 suppressed the migration and invasion of GBM cell. a and c Cell migratory ability of the control group and the AZD9291-treated groups were detected by wound healing assay in U87 and U251 cells. b and d Quantitative analysis of migratory cell numbers. e and g Effects of AZD9291 on invasion ability of U87 and U251 cells as examined by transwell assay. f and h Quantitative analysis of invading cell numbers. The numbers of migratory and invading cells were normalized to that of the control group. The values were presented as the means ± SEM, *P < 0.05, versus the control