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. 2019 May 17;10:1003. doi: 10.3389/fimmu.2019.01003

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Copyright © 2019 Wei, Wang, Wang, Wang, Liu, Han, Fu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone caused BMECs death. (A–C) The changes of BMECs morphology were measured after treatment with different concentrations of histone for 16 h (400×). Three independent experiments were carried out by light microscope analyses. (A) Controls. (B) BMECs treated with histone (100 μg/mL). (C) BMECs treated with histone (200 μg/mL). (D) Histone induced cytotoxicity to BMECs. The cytotoxicity of BMECs was determined by LDH Cytotoxicity Assay Kits after treatment with different concentrations for 16 h. Lysis provided by LDH Cytotoxicity Assay Kits was used as positive controls. (E) Effects of histone on the viability of BMECs. BMECs were incubated with histone and examined by CCK-8 kits. Date are presented as mean ± SEM (n = 5). P < 0.05 were considered significant (^*P < 0.05, ^**P < 0.01, and ^***P < 0.001).