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. 2019 May 17;10:1100. doi: 10.3389/fimmu.2019.01100

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Copyright © 2019 Takata, Pachera, Frank-Bertoncelj, Kozlova, Jüngel, Whitfield, Assassi, Calcagni, Vries-Bouwstra, Huizinga, Kurreeman, Kania and Distler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic localization and basal expression in skin of OTUD6B-AS1 and OTUD6B. (A) OTUD6B-AS1 and OTUD6B are located on chromosome 8 and oriented head-to-head (GENCODE v27). (B) In the Leiden cohort, OTUD6B-AS1, and OTUD6B expression was analyzed in healthy control (HC), non-involved and involved skin of systemic sclerosis patients (SSc) using next generation sequencing [HC: n = 6, SSc (non-involved): n = 4, SSc (involved): n = 10, (22)]. (C) In the Zurich cohort, OTUD6B-AS1, and OTUD6B expression was measured in HC and non-involved SSc patients skin by qPCR (HC: n = 5, SSc (non-involved): n = 6). Expression level was normalized using RPLP0. (C). Data are shown as single values and mean. Statistical analysis was performed by unpaired t-test. N.S, not significant.