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. 2019 May 17;13:484. doi: 10.3389/fnins.2019.00484

Figure 1.

Figure 1

EA effectively reduces pain hypersensitivity in CCI and KOA mice. (A,B) Time course of tactile threshold in response to von Frey filaments. (C,D) The noxious heat stimulus (53°C) caused a change in the thermal thresholds. The effect of tactile (A) and thermal (C) withdrawal thresholds changes in CCI mice. The change of tactile (B) and thermal (D) withdrawal thresholds of KOA mice caused by EA. A motion map of the EA-conditioned CPP test in CCI (E) and KOA mice (F). G,H are summary values of motion trajectories. EA (1 mA and 0.1 ms) at 2 Hz was administered for 30 min, once a day starting from the 8th to the 14th day in the CCI model and starting from the 15th to 21st day in the KOA model. Control group consisted of sham-operated mice. Data are expressed as the means ± SEM (n = 12 in each group). In A–D, *p < 0.05, compared with the control group; #p < 0.05, compared with the model group; In panels G,H,*p < 0.05, compared with the bright box time duration percent before EA; #p < 0.05, compared with the dark box time duration percent before EA.