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Neaumycin B BGC (neu). (A) Modular and domain architecture of the PKS genes and predicted structure of the growing polyketide. (B) Amino acid sequence alignments of the domain active sites. Red asterisks denote domains with mutations that may account for change of function. Black arrows denote specific amino acid positions where changes may account for domain inactivation. For full alignments see the Supporting Information, Figures S3–S7.
