Table 1.
Effect of Asparagus adscendens extract treatment on oxidative parameters in the cortex and hippocampus
| Treatment | TBARS (nmol/mg protein) | Reduced GSH (µmol/g of wet tissue) | Catalase (µ moles of H2O2 oxidized/mg of protein) | Nitrite level (ng/g of wet tissue) |
|---|---|---|---|---|
| Cortex | ||||
| Naïve | 10.26±0.82 | 48.33±4.04 | 2.87±0.26 | 277±21.28 |
| Vehicle control | 25.24±1.11* | 22.91±1.36* | 1.69±0.15* | 825±5.14* |
| IMP 15 mg/kg | 13.05±1.10# | 30.84±1.15 | 2.14±0.14 | 521±9.62# |
| AAE 25 mg/kg | 19.88±0.81# | 21.92±2.47 | 1.59±0.14 | 712.3±12.4# |
| AAE 50 mg/kg | 15.35±2.07# | 25.24±1.71 | 2.12±0.12 | 626.83±12.94# |
| AAE 100 mg/kg | 10.87±0.89# | 35.12±3.06$ | 2.99±0.07# | 472±20.57# |
| Hippocampus | ||||
| Naïve | 10.12±1.03 | 42.66±5.06 | 2.58±0.23 | 242.66±17.17 |
| Vehicle control | 22.33±1.56* | 21.25±1.59* | 1.61±0.13* | 814.16±8.41* |
| IMP 15 mg/kg | 11.73±1.11# | 28.45±2.15 | 2±0.04 | 529±15.68# |
| AAE 25 mg/kg | 18.62±0.97# | 22.48±1.96 | 1.32±0.08 | 718.2±15.12# |
| AAE 50 mg/kg | 14.67±0.79# | 24.11±1.45 | 1.86±0.05 | 605.33±12.31# |
| AAE 100 mg/kg | 12.50±0.94# | 33.18±2.94ψ | 2.76±0.09# | 513±10.88# |
Values were expressed as mean±SEM. The significance level was considered as P<0.05 (Student-Newman-Keuls test). *As compared with Naïve, #As compared with vehicle control. Vehicle control=Saline; intraperitoneal, IMP 15=Imipramine 15 mg/kg; intraperitoneal, AAE 25, 50, and 100=Asparagus adscendens extract 25, 50, and 100 mg/kg; i.p., SEM=Standard error of mean, TBARS=Thiobarbituric acid-reactive substance, GSH=Glutathione, $As compared to AAE 25 mg/kg; ψAs compared to AAE 50 mg/kg