Table 2. Performance of BKV viral load for the prediction of BKV-associated nephropathy, using a commercial and an in-house QPCR test.
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (CI 95%) | NPV % (CI 95%) | |
---|---|---|---|---|
Plasma viral load (copies/ml) | ||||
≥3.8 log (commercial PCR kit) | 88 (47-98) | 96 (90-99) | 64 (31-89) | 99 (94-100) |
≥4.1 log (commercial PCR kit) | 88 (47-98) | 98 (93-100) | 77 (40-97) | 99 (94-100) |
≥6.1 log (in-house method) | 87 (81-93) | 100 (94-100) | 73 (39-94) | 100 (91-100) |
Legend: CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; qPCR, quantitative real-time polymerase chain reaction.