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A schematic presentation of the Hedgehog signaling pathway and the drugs that interfere with this pathway in DTF. The graph depicts that inhibition of the Hedgehog pathway, by SMO inhibitors, works by blockage of Smoothened (SMO), a key regulator of downstream signaling by GLI transcription factors. The compound triparanol is known for inhibition of the cholesterol biosynthesis but can also interfere with Hedgehog signaling molecules including the Hedgehog ligand receptor Patched 1.
