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. 2019 May 15;30(5):632–650. doi: 10.1089/hum.2018.192

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Copyright 2019, Mary Ann Liebert, Inc., publishers

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Figure 1. — Long-term effects of recombinant adeno-associated virus (rAAV) Mfrp treatment on the rescue of retinal function in Mfrp KI/KI mice. (A) Representative images of Mfrp immunostaining (green) in rAAV-Mfrp and sham-treated control eyes. The arrows point to the retinal pigment epithelial (RPE) layer. (B) Representative images of M-opsin staining (red) in a rAAV-Mfrp treated and sham-treated control eye from the same animal. The arrows highlight the opsin immunostaining. (C) Analysis of cone photoreceptor count across the retina 9 months after rAAV-Mfrp injection. Cone survival was analyzed by counting the number of cones using S and M opsin immunostaining. There was a significantly greater number of cones in dorsal central and ventral mid-peripheral regions of rAAV-Mfrp-treated eyes compared to sham-treated eyes (p < 0.032). (D) Analysis of cone photoreceptor lengths across the retina in eyes 9 months after rAAV-Mfrp treatment. rAAV-Mfrp-treated eyes (n = 3) were compared to sham-treated control eyes (n = 3). Cone photoreceptor opsin immunostaining length was significantly longer in treated eyes in the central region compared to control eyes (p < 0.01). Color images are available online.