Table A2.

Table of the 33 model parameters optimized using the initial value as given in the table for the 7 patients (studied in section 3.4) from Yamamoto et al. [11] that showed liver failure.

Parameter	Nominal Value	Patient Identification Number
		ID114	ID123	ID131	ID29	ID45	ID 145	ID135
M	10.041128	10.7480	10.0211	10.0173	10.0396	9.9112	10.0552	10.0425
KIL6	1.5	3.9280	3.2484	1.6583	1.5000	1.0530	1.4620	1.4464
κIL6	0.9	3.9040	0.7807	0.9043	0.9000	1.0276	0.9117	0.9800
VJAK	20,000	20,000	20,000	20,000	20,000	20,000	20,000	20,000
${\mathrm{K}}_{\text{M}}^{\text{JAK}}$	10,000	10,000	10,000	10,000	10,000	10,000	10,000	10,000
κJAK	0.4	1.4695	1.1701	0.3941	0.4000	0.5844	0.4330	0.3804
[proSTAT3]	2	6.1276	3.0179	1.9367	1.9736	1.9422	1.9866	1.9897
VST3	750	750.0337	750.0022	750.0003	750.0001	750.0006	750.0000	749.9999
${\text{K}}_{\mathrm{M}}^{\mathrm{S}\text{T}3}$	0.4	1.0194	1.2485	0.4001	0.4000	0.4115	0.4096	0.3752
κST3	0.1	0.0987	0.1614	0.1000	0.1000	0.1017	0.1152	0.1116
VSOCS3	24000	24000	24000	24000	24000	24000	24000	24000
${\mathrm{K}}_{\text{M}}^{\text{SOCS}3}$	0.0007	0.0007	0.0007	0.0007	0.0007	0.0009	0.0007	0.0007
κSOCS3	0.4	0.4871	0.3970	0.4000	0.4000	0.1913	0.3855	0.3847
${\mathrm{K}}_{\text{I}}^{\text{SOCS}3}$	0.015	0.0139	0.0149	0.0150	0.0150	0.0150	0.0147	0.0150
VIE	250	250.12	250.01	250.00	249.99	249.99	249.99	249.99
${\mathrm{K}}_{\text{M}}^{\text{IE}}$	18	19.1762	18.1366	18.0041	18.0055	18.0474	18.0014	17.9778
κIE	5	6.9573	5.3009	5.0022	4.9925	4.9951	5.0061	4.9493
kdeg	7	6.3119	7.2057	7.0017	6.9977	7.1109	6.9982	7.0171
κECM	33	33.9672	33.0645	32.9999	33.0004	32.9871	33.0004	32.9939
kGF	0.113	0.1677	0.1214	0.1130	0.1130	0.1128	0.1166	0.1103
κGF	0.23	0.3384	0.2453	0.2300	0.2300	0.2291	0.2298	0.2302
kup	0.06	0.0577	0.0590	0.0600	0.0600	0.0598	0.0600	0.0600
kQP	0.007	0.0079	0.0069	0.0070	0.0070	0.0056	0.0070	0.0070
kPR	0.0044	0.0043	0.0044	0.0044	0.0044	0.0034	0.0044	0.0044
kRQ	0.054	0.0517	0.0536	0.0540	0.0540	0.0509	0.0507	0.0547
kprol	0.02	0.0202	0.0202	0.0200	0.0200	0.0277	0.0220	0.0144
kreq	0.1	0.1407	0.0999	0.1000	0.1000	0.1308	0.1013	0.0987
θreq	8	9.9514	8.2151	7.9998	7.9994	7.9845	8.0009	8.0182
βreq	3	3.9615	3.1587	3.0021	3.0000	2.9657	2.9990	2.9563
Kcd	0.1	0.1390	0.1089	0.1000	0.1000	0.1001	0.1006	0.1003
θcd	0.011050	0.0117	0.0099	0.0111	0.0111	0.0108	0.0128	0.0114
βcd	0.026046	0.0180	0.0270	0.0257	0.0249	0.0198	0.0260	0.0234
kG	0.000657	0.000588	0.000601	0.000613	0.000614	0.000400	0.000497	0.000574