Table 3.

Torque Teno Virus Level Stratified According to Baseline Characteristics of the Study Cohort

Characteristic	TTV, Copies/mL, Median (IQR)
	Variable Positive	Variable Negative	P Value
Recipient characteristics
Recipient age >55 ya	9.3 × 108 (3.2 × 107–3.7 × 109)	2.8 × 107 (1.8 × 106–3.0 × 108)	< .01
Recipient female	1.0 × 108 (1.7 × 106–3.8 × 109)	5.4 × 107 (8.5 × 106–1.7 × 109)	.835
Donor characteristics
Living donor	1.2 × 108 (4.8 × 106–4.0 × 109)	5.8 × 107 (7.0 × 106–2.0 × 109)	.928
Donation after circulatory death	1.5 × 108 (9.3 × 106–3.1 × 109)	5.9 × 107 (6.9 × 106–2.2 × 109)	.815
Donor age >58 ya	5.0 × 108 (1.5 × 107–4.1 × 109)	3.2 × 107 (2.8 × 106–1.2 × 109)	.030
Donor female	5.6 × 107 (7.0 × 106–3.0 × 109)	8.5 × 107 (4.5 × 106–2.2 × 109)	.633
Transplant characteristics
Retransplantation	3.1 × 107 (5.8 × 105–2.8 × 109)	1.3 × 108 (8.3 × 106–2.8 × 109)	.090
ABO-incompatible transplantation	4.9 × 109 (1.7 × 109–1.5 × 1010)	5.6 × 107 (6.1 × 106–2.0 × 109)	.036
HLA-A/B/DR mismatch >3a	7.1 × 107 (1.2 × 107–2.1 × 109)	6.1 × 107 (4.8 × 106–3.0 × 109)	.969
Donor-specific antibody	4.9 × 109 (1.6 × 109–1.4 × 1010)	5.8 × 107 (6.1 × 105–2.0 × 109)	.438
CDCXM conversionb	4.2 × 107 (8.1 × 106–1.3 × 109)	8.5 × 107 (6.9 × 106–2.6 × 109)	.482
Cold ischemia time >14 ha	5.6 × 107 (7.2 × 106–2.3 × 109)	1.2 × 108 (6.3 × 106–2.8 × 109)	.877
Delayed graft functionc	1.4 × 108 (1.2 × 107–2.8 × 109)	5.7 × 107 (5.8 × 106–2.2 × 109)	.504

The Mann–Whitney U test was used for comparing continuous data and group comparisons were made using the χ² test. Exact tests were used where applicable.

Abbreviations: CDCXM, complement-dependent cytotoxicity crossmatch; HLA, human leukocyte antigen; IQR, interquartile range; TTV torque teno virus.

^aCutoff defined by median.

^bWe allowed for peritransplant CDCXM conversion following a local protocol.

^cDelayed graft function was defined by the necessity of >1 renal replacement therapy posttransplantation.