Figure 5.

Inhibition of the cytokines production^a. ^aRAW264.7 cells were pretreated with compound 4e in a series of concentrations (10, 5, 2.5, 1.25 μM) for 1 h, incubated with LPS (0.5 μg/ml) for 24 h. NO releasing was measured using Griess Reagent assay. The levels of TNF-α and IL-6 in the culture medium were measured by ELISA. *** p< .001, **p < .01, *p < .05 versus LPS group.