Table 4.
Hazard ratios with 95% confidence intervals of top three PLA2G2A variants influencing sPLA2-IIA mass levels and incident CVD
|
PLA2G2A variants (minor allele) |
Homozygous for non-effect allele |
Intermediate genotype | Homozygous for effect allele |
HR (95% CI) per minor allele |
P Value for additive model |
|---|---|---|---|---|---|
| rs11573156 (G) | 1 | 1.06 (0.80-1.40) | 1.36 (0.79-2.34) | 1.11 (0.89-1.38) | 0.34 |
| rs2307246 (T) | 1 | 1.12 (0.90-1.39) | 0.32 | ||
| rs4744 (T) | 1 | 1.11 (0.89-1.38) | 0.37 |
HRs (95% CI) are adjusted for age, sex, randomization treatment assignment, region and measures of subpopulation stratification HR denotes hazard ratio; and CI, confidence interval.