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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2019 Mar 1;180(4):249–257. doi: 10.1002/ajmg.b.32720

TABLE 2.

Parent-offspring tetrachoric correlations for drug abuse and alcohol use disorder by relationship type

G + R offspring R only offspring G-only offspring G + R offspring R only offspring G-only offspring G + R offspring R only offspring G-only offspring G + R off-spring R only offspring G-only offspring
Type of parent Rearing defined as: Drug abuse tetrachoric correlations (SEs)a Drug abuse tetrachoric correlations (SEs)b Alcohol use disorder tetrachoric correlations (SEs)a Alcohol use disorder tetrachoric correlations (SEs)b
G + R, R only and G only ≥5 years 0.30(0.03) 0.19 (0.04) 0.22 (0.04) 0.25 (0.03) 0.15 (0.04) 0.18 (0.04) 0.18 (0.03) 0.14 (0.03) 0.17 (0.03) 0.16 (0.03) 0.11 (0.03) 0.15 (0.03)
G + R and G only 0.29 (0.01) 0.22 (0.02) 0.19 (0.01) 0.17 (0.02) 0.21 (0.01) 0.17 (0.01) 0.16 (0.01) 0.14 (0.01)
R only and G only 0.20 (0.04) 0.17 (0.04) 0.11 (0.05) 0.14 (0.05) 0.07 (0.04) 0.16 (0.04) 0.02 (0.04) 0.13 (0.04)
G + R and R only 0.26 (0.01) 0.13 (0.02) 0.21 (0.01) 0.08 (0.02) 0.20 (0.01) 0.07 (0.01) 0.17 (0.01) 0.04 (0.01)
Weighted average 0.28 (0.01) 0.15 (0.01) 0.21 (0.01) 0.20 (0.01) 0.09 (0.01) 0.16 (0.01) 0.20 (0.01) 0.08 (0.01) 0.17 (0.01) 0.16 (0.00) 0.05 (0.01) 0.14 (0.01)
Test of heterogeneity 0.148 0.156 0.546 0.220 0.188 0.793 0.478 0.088 0.989 0.663 0.052 0.915
G + R, R only and G only ≥10 years 0.34(0.05) 0.17 (0.07) 0.22 (0.07) 0.29 (0.06) 0.14 (0.08) 0.17 (0.07) 0.22 (0.04) 0.09 (0.05) 0.11 (0.05) 0.20 (0.04) 0.07 (0.05) 0.08 (0.05)
G + R and G only 0.28 (0.01) 0.21 (0.02) 0.19 (0.02) 0.16 (0.02) 0.20 (0.01) 0.18 (0.01) 0.15 (0.01) 0.15 (0.01)
R only and G only 0.22 (0.08) 0.12 (0.09) 0.18 (0.09) 0.10 (0.09) 0.06 (0.02) 0.13 (0.06) 0.06 (0.07) 0.09 (0.06)
G + R and R only 0.25 (0.02) 0.14 (0.02) 0.22 (0.02) 0.09 (0.03) 0.20 (0.01) 0.06 (0.02) 0.17 (0.02) 0.04 (0.02)
Weighted average 0.27 (0.01) 0.15 (0.02) 0.20 (0.02) 0.21 (0.01) 0.10 (0.02) 0.16 (0.02) 0.21 (0.01) 0.06 (0.01) 0.17 (0.01) 0.16 (0.01) 0.04 (0.02) 0.14 (0.01)
Test of heterogeneity 0.311 0.574 0.544 0.178 0.573 0.781 0.892 0.713 0.294 0.223 0.749 0.255
a

Controlling for year of birth and sex of proband.

b

Controlling for DA (or AUD) in other parent, year of birth and sex of proband.