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. 2019 May 21;10(36):3315–3327.

Figure 2. Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic drugs.

Figure 2

OVCAR8 cells (A) and SKOV3 cells (B) exhibited reduced viability by MTS assay when co-treated for 24 h with the DUSP6 inhibitor BCI and either paclitaxel or carboplatin compared to either chemotherapeutic agent alone. OVCAR8 cells (C) and SKOV3 cells (D) were treated with various doses of carboplatin alone or in combination with 3.75 uM BCI for 24 h. Cell viability was measured with MTS assay. A synergistic effect was observed with the addition of BCI to carboplatin at all doses tested. Error bars represent standard deviation from ≥3 biological replicates. For clarity, only significance between Ctrl vs. BCI and single agent chemo vs. BCI+chemo are indicated on the graph. Error bars represent standard deviation of ≥3 biological replicates. *p<0.05, **p<0.005; ***p<.0005, ****p<.00005.