Table 3:

Estimation of Heritability Explained by Variants on Exome Array. We estimate the heritability based upon a baseline model with seven different functional categories. The reported heritability ${\widehat{h}}^2$ is based upon the cumulative value from the functional categories with significant heritabilities. We also report the standard deviation (se $({\widehat{h}}^2)$)and p−values, estimated using jackknife.

Annotation	Phenotype	Heritability Estimates
		${\widehat{h}}^2$	(se $({\widehat{h}}^2)$)	P−Value
All Variants	Age of Initiation of smoking	.06	.0049	7.7×10−35
	Cigarettes per Day	.09	.0019	< 2.2×10−303
	Pack Years	.10	.0022	< 2.2×10−303
	Smoking Initiation	.14	.0007	< 2.2×10−303
	Drinks per Week	.16	.0089	7.3×10−73
Rare Coding Variants (MAF<.01)	Age of Initiation of smoking	.011	.0015	2.8×10−2
	Cigarettes per Day	.010	.0006	1.7×10−2
	Pack Years	.018	.0007	8.5×10−6
	Smoking Initiation	.022	.0002	3.9×10−16
	Drinks per Week	.020	.0013	1.8×10−7