Table 4: Estimation of Genetic Correlation Between Smoking and Drinking Traits.

We estimate genetic correlations between five smoking and drinking traits. Genetic correlation estimates $({\widehat{r}}_{\text{g}})$, their standard deviation (se $({\widehat{r}}_{\text{g}})$)and p−values are reported.

Trait 1	Trait 2	Genetic Correlation
		${\widehat{r}}_{\text{g}}$	se $({\widehat{r}}_{\text{g}})$	P−value
A. Aggregated Genetic Correlation Induced by All Variants on the Exome Array
Drinks per Week	Smoking Initiation	.43	.06	1.7×10−11
Drinks per Week	Age of Initiation of Smoking	.01	.13	9.3×10−1
Drinks per Week	Pack Years	.22	.10	2.6×10−2
Drinks per Week	Cigarettes per Day	.20	.09	3.1×10−2
Smoking Initiation	Age of Initiation of Smoking	−.64	.11	1.1×10−8
Smoking Initiation	Pack Years	.45	.08	4.9×10−8
Smoking Initiation	Cigarettes per Day	.10	.07	1.5×10−1
Age of Initiation of Smoking	Pack Years	−.63	.17	2.1×10−4
Age of Initiation of Smoking	Cigarettes per Day	−.26	.16	9.9×10−2
Pack Years	Cigarettes per Day	.77	.13	2.2×10−9
B. Genetic Correlation Induced by Rare (MAF < 1%) Nonsynonymous Variants
Drinks per Week	Smoking Initiation	.49	.08	1.2×10−10
Drinks per Week	Age of Initiation of Smoking	−.04	.30	8.9×10−1
Drinks per Week	Pack Years	.08	.02	2.7×10−4
Drinks per Week	Cigarettes per Day	.09	.02	5.2×10−5
Smoking Initiation	Age of Initiation of Smoking	−1.10	.21	1.3×10−7
Smoking Initiation	Pack Years	.63	.08	1.5×10−14
Smoking Initiation	Cigarettes per Day	.23	.08	3.3×10−3
Age of Initiation of Smoking	Pack Years	−1.10	.33	1.5×10−3
Age of Initiation of Smoking	Cigarettes per Day	−.69	.32	3.2×10−2
Pack Years	Cigarettes per Day	.87	.14	1.4×10−9