Table 2.

Left ventricular ejection fraction (LVEF) variations according to the development of a cardiac event (CE) or protocol defined decrease in LVEF (Wilcoxon rank-sum test)

Time point	Median LVEF (assessed by core lab), % [IQR]			P value
	Overall study population (N = 30)	No events (N = 27)	CE or asymptomatic decline in LVEF (N = 3)
Baseline	45.0 [43, 47]	46.0 [43, 47]	43.0 [40, 44]	0.10
6 weeks	45.0 [43, 47]	45.0 [43, 48]	41.0 [40, 43]	0.04
12 weeks	47.5 [44, 53]	49.0 [44, 53]	41.0 [35, 45]	0.07
24 weeks	45.0 [41, 48]	46.0 [41, 49]	31.5 [25, 38]	0.04
End of treatment (EOT)	48.0 [42, 50]	48.0 [43, 50]	31.0 [29, 37]	0.01
6 months post-EOT	47.0 [45, 50]	47.0 [45, 50]	43.5 [41, 46]	0.16

IQR interquartile range