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. 2019 May 24;10:2313. doi: 10.1038/s41467-019-10332-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — DNA double-strand breaks at replication fork barriers. a Scheme of replication fork barriers (RFBs) at yeast ribosomal DNA locus. b The total number of RFB-related one-ended DSBs (peaks as defined in c calculated from the difference of Watson and Crick strand reads (Methods)). DSBs per cell values and SD are shown (n = 39, Methods). Source data are provided as a Source Data file. c Quantified DSB signal in RFB region. RFB1 and RFB2 are indicated by the red boxes on the top. The blue boxes mark Fob1 protein binding sites mapped in vitro. The yellow star indicates Top1 cleavage site. The signal originating from rDSB-1 and rDSB-2 is presented in blue, the signal from rDSB-3 we discovered is presented in red